consumption of KRG resulted in significant improvement in pulse
wave reflection, as measured by AI, compared to a control in
Decrease in AI occurred without affecting brachial BP.
Wave reflection is an independent predictor of CVD.
Decrease in AI was observed after ginsenoside consumption, but not after consumption of polysaccharide fraction.
KRG showed similar effects on BP as some antihypertensive treatments.
These findings are of interest because there is a strong association between indices of wave reflection and CVD risk.
Acute consumption of Rg3-KRG extract resulted in significant reduction in aortic AI in healthy individuals.
At the end of posttreatment period, additional hemodynamic measures show more content
The observations demonstrate that Rg3-KRG is a vasoactive agent, which lowers brachial BP and may have an additional favourable impact on aortic AI.
An Rg3-KRG supplement may be used as a CVD risk management strategy.
Consumption of AG capsules significantly improved arterial stiffness compared to a control in individuals with type 2 diabetes and associated hypertensionfollowing 3 month supplementation.
Treatment with AG resulted in an improvement of vascular endothelial function and decreased arterial stiffness, most likely through the NO pathway.
These findings are of interest because arterial stiffness and endothelial dysfunction have been clinically linked to a decreased NO generation and increased NO inactivation, leading to increased CVD risk.
A decrease in peripheral systolic BP and AI was also observed. This finding suggests that an earlier return of the wave reflection from the periphery, a distinctive feature of stiffer arteries in hypertension, is associated with an increase in systolic BP. Therefore, the observed changes in AI may have occurred dependent of their effects on systolic show more content
Improvement in FMD was not seen with the polysaccharide fraction.
The observations demonstrate that isolated ginsenosides play an important role in vasodilation.
This is the first study to provide clinical evidence that the ginsenoside fraction of KRG may mediate the stimulation in the vascular endothelium.
The study had three groups in total: control, non-treated hypertensive, and ginseng-treated hypertensive.
Acetylcholine (Ach), bradykinin (BK) and sodium nitroprusside (SNP) were the vasodilating agents used to measure forearm bloodflow.
The vasodilatory response to Ach was an impaired endothelium. The vasodilatory response to ginseng was a not so impaired endothelium, and was even comparable to the normal control group. This suggests that endothelial dysfunction due to hypertension can be improved by administering KRG. This will lead to the production of NO and restore the vascular responsiveness of NO to a normal level.
The results demonstrated that long-term administration of KRG could restore endothelial dysfunction associated with hypertension. This suggests that KRG can be used to prevent the development of atherosclerosisdue to
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